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Second, incubation with acetaldehyde downregulated expression of two important genes involved in aerobic glycolysis, Glut1 and Hif-1a in T cells.29-31 Third, several metabolic signal pathways including mTOR, AKT, 4E-BP1, which are involved in aerobic glycolysis in T cells,29-31 were suppressed after exposure to acetaldehyde in vitro with the strongest inhibition of pAKT activation

10.1016/j.neuron.2014.12.007 Neuron 95 PisanuA.LeccaD.MulasG.WardasJ.SimbulaG.SpigaS.et al (2014)

2021;49:D15417

(2024) identified universally applicable gut microbiota biomarkers and their association with high-altitude adaptation